InVivo in the News

InVivo Therapeutics : Rehab Improving AIS Grade of SCI May Help Lower Lifetime Hospitalization Costs

Published: September 5, 2017

(4-Traders.com)A study published recently in Neurosurgery estimates the lifetime economic costs of spinal cord injury (SCI) associated with hospitalizations in relation to American Spinal Injury Association Impairment Scale (AIS) grade.

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InVivo touts 2 patient recoveries in Inspire trial

Published: June 28, 2017

(MassDevice) InVivo Therapeutics (NSDQ:NVIV) said today that 2 patients in the Inspire trial of its Neuro-Spinal Scaffold have shown significant improvements in motor recovery assessments. The Cambridge, Mass.-based company’s Neuro-Spinal Scaffold is designed to be surgically implanted following acute spinal cord injuries to act as a physical substrate for nerve sprouting.

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Two spinal cord injury patients show improvement after receiving InVivo’s Neuro-Spinal Scaffold; shares ahead 13% premarket

Published: June 28, 2017

(Seeking Alpha)InVivo Therapeutics (NASDAQ:NVIV) perks up 13% premarket on modest volume in response to its announcement that two spinal cord injury patients in the INSPIRE study who received its Neuro-Spinal Scaffold have improved from sensory incomplete AIS B status to motor incomplete AIS C, the second and third patients to reach this level.

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InVivo Therapeutics (NVIV) Announces Seventh Patient Conversion In The INSPIRE Study Of The Neuro-Spinal Scaffold

Published: March 28, 2017

(BioSpace.com) CAMBRIDGE, Mass.–(BUSINESS WIRE)–InVivo Therapeutics Holdings Corp. (NVIV) today announced that the patient enrolled in January in the INSPIRE study of the Neuro-Spinal Scaffold has improved from a complete AIS A spinal cord injury (SCI) to an incomplete AIS B SCI in the time between the one-month and the two-month evaluations. This is the seventh out of the 11 patients (63.6% conversion rate) with at least one month of follow-up to have had an AIS grade improvement. Two additional patients are early in follow-up and have not yet had their one-month visit. The AIS conversion rate observed in the INSPIRE study to date is considerably higher than published rates observed in a range of SCI natural history databases that are all below 25%.

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Using a Mini-Scaffold to Help Treat Spinal Cord Injury

Published: February 28, 2017

(Bioscience Technology) Patients suffering from complete spinal cord injuries have little to no treatment options that provide meaningful improvement in patient outcomes.
Cambridge, Mass.-based InVivo Therapeutics is trying to change that. Co-founded in 2005 by MIT professor Robert Langer, and surgeon-scientists Joseph Vacanti, M.D., the company has developed a small, bioresorbable and biocompatible device called the Neuro-Spinal Scaffold, to help patients with complete thoracic spinal cord injuries regain some function.

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The Edison of Medicine

Published: February 23, 2017

(Harvard Business Review) One morning last year, James Dahlman came to Bob Langer’s office at MIT’s Koch Institute for Integrative Cancer Research to say good-bye. He was meeting with Langer and Dan Anderson—his doctoral advisers. The 29-year-old was about to take up his first faculty position, in the biomedical engineering department at Georgia Tech, and he wanted their advice.

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InVivo’s Perrin on Developments in Spinal Cord Injury Treatment

Published: February 14, 2017

(Bloomberg Markets AM) GUEST: Mark Perrin, CEO of InVivo Therapeutics (NVIV), on highlights from the BIO CEO conference, and developments in the company’s spinal cord injury treatment.

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Experimental scaffold hasn’t reversed her paralysis, but she’s embraced life ‘with wheels as legs’

Published: November 21, 2016

(STAT News) Jesi Stracham used to captivate biotech investors and inadvertently move markets with social media posts documenting her dogged quest to get out of her wheelchair and back onto her feet.

These days, the energetic 24-year-old North Carolina resident goes online to tell a different story. Many of her Facebook and Instagram posts show her competing in off-road vehicle races, an adaptive water skiing competition, and a pageant for women with disabilities.

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We’re One Step Closer to Reversing Paralysis

Published: November 17, 2016

(Tonic) A new implant joins a small set of treatments offering hope to people with spinal injuries.

Jordan Fallis had been hurt before: a broken arm, broken ribs, a fractured wrist, a fractured hip—but that didn’t deter him from riding. BMX was his passion, and although he always wore protective gear, injuries and brushes with death were things he accepted as part of the deal. One morning in October 2014, the then 24-year-old went to his usual spot in Peoria, Arizona, to practice the routine flips and jumps he’d done hundreds of times before. Well into the afternoon, he entered a backflip but under-rotated, hit the front wheel first, and then fell to the ground. He felt his body tingle like an electric current was passing through it. He remembers hoping he had pinched a nerve.

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Transforming SCI treatment — The promise of InVivo’s Neuro-Spinal Scaffold 

Published: October 21, 2016

(Becker’s Spine Review) About a decade ago, a novel technology called the Neuro-Spinal Scaffold for patients with spinal cord injury came to fruition. Today, Cambridge, Mass.-based InVivo Therapeutics’ INSPIRE study is underway to prove the technology’s efficacy.

A bioresorbable polymer scaffold, the Neuro-Spinal Scaffold is designed for implantation at the injury site within a spinal cord contusion, degrading over several weeks. The scaffold is composed of two biocompatible and bioresorbable polymers — Poly(lactic-co-glycolic acid) and Poly-L-Lysine. These polymers are manufactured to create a porous scaffold encouraging cellular attachment and neurite outgrowth.

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